±«Óătv

Non-specific human defence systems against disease

The body is constantly defending against attacks from . The first line of defence against infection stops the pathogens from entering your body. These first lines are general defences, and are not specific to fight against certain types of pathogen. They are called non-specific, and they can be physical or chemical barriers.

Skin

The skin covers almost all parts of your body to prevent infection from pathogens. If it is cut or grazed it immediately begins to heal itself, often by forming a scab, which prevents infection as the skin acts as a physical barrier. Parts of the body that do not have skin have developed other ways to prevent infection. For example, the eyes produce tears, which contain , and these are chemical barriers.

A diagram of skin and its component parts such as nerve endings and fatty tissue
Figure caption,
A cross-section of skin

Nose

The nose has internal hairs, which act as a physical barrier to infection. Cells in the nose produce . This traps pathogens before they can enter the lungs. When the nose is blown, mucus is removed and any pathogens are trapped within it.

Trachea and bronchi

Ciliated cells
Figure caption,
Cilliated cells reduce the amount of mucus and pathogens entering the lungs

The runs from the nose towards the lungs. The cells that line the trachea also have hairs called , which are much smaller than those in the nose. These are called . The ciliated cells waft their hairs and move mucus and pathogens upwards towards the throat where it is swallowed into your . Other cells called create the mucus in order to trap pathogens. The production of mucus in your airways is a physical barrier.

Stomach

Stomach acid is part of the body's non-specific first line of defence. It is hydrochloric acid and while it does us no harm, it is strong enough to kill any pathogens that have been caught in mucus in the airways or consumed in food or water. Stomach acid is a chemical barrier against infection.

Learn more about human defence systems against infection with Dr Alex Lathbridge.

Learn about human defence systems against infection with Dr Alex Lathbridge.