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Dusana Dorjee is a cognitive neuroscientist at the at Bangor University and author of Mind, Brain and the Path to Happiness. 听She joins Jenni Murray to talk about the latest neurological research into how stress affects the brain and the mind.

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Thanks to advances in neuroscience, we now understand far more about how pressures in today鈥檚 world can impact upon our minds.听 Ruby Wax knows better than most, having journeyed through deep depression to obtaining an MA from Oxford in . So just how mad is our world? And what are the ways to manage it when it comes to our mental health?听 Ruby Wax and听writer Madeleine Bunting join Jenni to discuss.

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Sane New World, Taming the Mind by Ruby Wax is published by Hodder.

Nearly half a million people in the UK believe that they have work-related stress at a level that is making them ill.听 Undue pressures and demands at work because of workload, deadlines, the environment you work in or your colleagues can lead to critical levels of stress. And yet work-related stress is the elephant in the room in many workplaces. The charitybelieves that stressed workers are suffering in silence and employers aren鈥檛 doing enough to tackle stress. A third of workers polled by the charity said that they would not be able to talk openly to their line manager if they felt stressed.听

From casual conversations, to psychological support, knowing how to deal with the everyday strains of your job is important. Jenni speaks to Sarah Mitchell who suffered repeated panic attacks at work and to occupational therapist Dr Almuth McDowell about why so many of us are suffering in silence.

Supporting a partner who has mental health issues can be a real challenge.听听We hear from Phil Wield whose partner Cathy spent years in hospital battling psychotic depression and Kate whose partner Glen is still battling with his problems. What鈥檚 it like living day to day with someone who is听depressed - trying to juggle work, life and kids听while remaining positive?听 They鈥檒l tell Jenni Murray about听 the strain it can put on a relationship,听 what鈥檚 helped them cope and how you can come out the other side.

If you鈥檙e concerned about the state of mind of someone close to you, what are the signs that could identify someone experiencing clinical depression rather than a low mood, or unhappiness? What should you do to support them, and what are your options if someone won鈥檛 acknowledge they need help? Dr Rina Dutta is a consultant psychiatrist and academic at , and will join Jenni Murray to talk about noticing changes that could point to mental illness.